I'm now shooting at a moving target here (very tounge in cheek), but my old aircraft maintenance coming out. Just some things to try if you haven't already and a reason for my suggestion.
Have you tried moving the scanner around in the car to see if that helps? (My 500 sitting on the console with a ducky just won't work, too much interference, move it to the passenger seat or my lap and things work fine.)
Have you tried another antenna or scanner (with the same antenna)? (Could be some weird combination of antenna, radio, propgation of RF, and vehicle. Using my 500 again, if I hook it to an external antenna while on the console, it works fine too. My 396 has no problems with a ducky in the same location.)
Does the scanner act up in other vehicles too or just one? (If in any car, then you have a radio problem, in only one car, then it seems to be the car causing the problem. If the ignition has a problem, it could be the problem though ignition would seem to cause problems at idle or when reving the engine while stopped.)
Do you have a static generator attached to any of your wheels (okay now I'm being dumb)? But if the problem is only while moving, then it would seem to be something that is only working while moving. Wheels or transmission (sensor lead open?).