Hi Chris!
I have the same radio, the Radio Shack USB programming cable, and both software packages as you. I'm also running MS Vista Home Premium and everything works fine!
First make sure you're using the latest versions of WIN97/PSREdit-300. I had problems with earlier versions.
When you have PSREdit-300 running, click on the Configuration pull-down menu, then click on Serial Port, then under Communications Settings, click on Search For Scanner. Does it automatically find your scanner? I found sometimes while the software is running, and the scanner is on, if you unplug the cable from the scanner, and plug it back in, it helps detect it's presence. Or, try turning the scanner off, then back on while the software is running and the cable is attached.
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