I've only had one problem with Win 10 and Zadig so far - the OS keeps prompting to update the drivers via Windows update (which would obviously return it to the factory drivers). Yet to find a workaround for that, but hopefully if I ignore it it will go away
In Win7 if you right-click an update in Windows Update you can tell the system to ignore it (which it seems to do for only a few iterations, but it does it at least). Do you have the same ability in 10?