As Steve mentioned, your not going to get much help without supplying much more details.
Let be be more specific:
What radio are you trying to program?
Which CPS are you using?
Which cable are you using to program the radio with?
Is this a serial cable or a USB cable? If a serial cable, which RIB are you using?
Have you set the CPS to use the correct connection? This means did you set the serial com port to what your really connected to or did you set the program to use the USB type connection?
What region of the world is the software and radio set for?
Last question, what version of Windows are you trying to use?
I guess I have another question, did you obtain this copy of the CPS directly from Motorola?