ARC-XT works fine on Win10 with no problems at all. As far as the cable, if you're talking about Uniden's USB-1 cable, it depends how old your cable is as to whether or not it will work with Win10. If it's an older cable that uses the Prolific PL2303HXA chipset it probably won't work. If it was purchased in 2013 or later it will most likely work with Win10.