Short answer is no.
To locate the folder where your settings are kept, select the Archive tab and click on the Folder tool button.
Windows Explorer will display the folder for your Configure.xml (radio settings) and Unitrunker.xml (logged trunked systems). If you want to err on the side of abundant caution - copy these files to another folder.
Ideally a re-install will look for these files in the same place. However, sometime people change the working folder and then forget so the re-install can't see the files.