Crossfire is ATI's name for the interface it uses to link 2 or more video cards together. If you linked 2 video cards of the same gpu speed together, you would effectively double the speed of your GPU speed. In using crossfire, you link the two video cards together inside the computer with a linking ribbon cable that comes with the video cards. One video card is a master, the other is a slave. You hook your monitor up to the master video card only. You can also do this with nvidia video cards, nvidia calls it SLI rather than crossfire.
As far as your mouse/keyboard, it really depends on the games you play. There is an advantage to having a laser mouse with a high dpi for first person shooters and things like that, the higher dpi makes the mouse movements quicker and more accurate. To be honest, I've never seen the point in upgrading keyboards.
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