Have you tried a least a second time there is a know hiccup when you start on a scanner the first time it wont connect even if it is connected. click connect or Auto Connect and then it will for some users immediately, even when its been used multiple times on the scanner previously it just won't show the first connect after a computer restart or reboot.
Have you checked the driver for the lastest 01.01.14 Uniden Driver, then deeper in the driver at baud rate and the what not, also in the scanners GPS setting for baud rate. You can search/check-out the forum, on the driver issues others have used to fix their Uniden scanners.