Yes. I've had it happen. Once the USB port was bad, and it had to be sent in for repair or replacement. I don't recall now. More recently, I've effectively bricked one of my older G5s when programming, and had to revert to an older firmware version(2.02 back to 1.35) to get it to come back. In that case, the firmware update software would connect, but PPS would not.
I'd start simple though, and try another computer, and then another cable that you know works. Hopefully, it's just a bad or incorrect cable. I'm assuming, you're using a home computer and not a work computer where your IT department might have turned off your USB ports. Recently at work I was trying to use another radio brand's programming software and it wouldn't connect until I turned off some other network connection software.