Both frequencies are simplex. It's just that 144.2 is the SSB calling frequency and 146.52 is the national FM simplex calling frequency. If you are on the road and have a SSB rig, plunk it down on 144.2, if only an FM rig, try 146.52. But you won't hear much, most people who may be traveling together in different vehicles will have their own "private" frequency, I know I do when on the road. Some people just operate on the various repeaters they come across. Out in the San Francisco area 146.52 is a popular frequency, there are a bunch of guys using it at night.