In the UHF band, it would be common for the frequencies transmitted from the base to the mobiles
to be in the 463.000 range, & the frequencies that the mobile would transmit back to the base to be
in the 468.000 range......UHF repeater frequencies usually have that 5 KC offset.
BUT........if you are trying to program an Icom F-121, that is a VHF radio, not a UHF radio.
The F-121 works in the 150.000 range only. For UHF service, you need a F-221.
However, the CS-100 software programming package works for both radios.