I would use the ignition sense but all my radios are in the trunk, plus I have handheld chargers in the trunk so I would just rather the whole fuse panel be on the ignition, and I'm so going to throw a Charge-Guard in while I'm at it.
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I'd add:
It's a whole hell of a lot easier to use the ignition sense leads on the radio. They draw very little current, and it would negate the need for the relay.
On the other hand, if you leave your car unattended for long periods of time, it's nice to have a positive way of disconnecting the power completely. I usually just pull my main fuse if I am leaving my truck for more than a week.
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