You'll have to tell us which system you want to program before anyone can give specific help...Be sure to give the URL of the system from the database so folks know which one you are looking for help...In general terms, it's no different than any other trunk system insofar as assigning quick keys and laying out the talkgroups into groups, and assigning group quick keys for them.
There are several applications that, with the purchase of a subscription (cheap), will allow you to download data from the database, which does much (though not all) of the work for you. ARC996, ProScan and FreeScan (which is free) will all do the job.
This article from our wiki gives you links to just about everything you will need to know to get started (including the Easier to Read manuals, which are at the bottom of)
Program your DMA Scanner - the RR Wiki
Mike