The tuner has various interface cables for Yaesu, Icom, Alinco, Kenwood and other popular amateur radios. With the interface cable it should tune the antenna when you push the tune button on the radio. For other radios I think it can be set up to tune automatically when the match is above a certain point but you would not want to tune with the amp on, tune at lower power then turn the amp on after its done tuning.
You will want the installation guide. that explains the connections for tuning.
Basically the tuner uses low power (a few watts) tunes quickly then you can switch in any amplification.
Uses the 'tune' button on most radios set up for 'AT'.