I did what you are doing for a while with an FT-60 and no problems. I put an NMO mount on the roof, the perminate mount right in the middle of the roof gets you so much better grounding and signal, it makes a huge difference. Be sure to remove all paint down to the metal on the inside of the vehicle where the mount bites to hold onto the metal so you get the best ground possible. An adapter from the radio to the 259 connection on the antenna wire was all it took and care when taking it on and off. A fender mount will work, but will have an uneven radiation pattern and will chip the paint on the fender. The NMO mount, you just remove when selling the car and put a cap over the hole, hardly is noticed, especially if it's a pick up truck, it can't even be seen.
I have found the Comet CA-4X4 antenna to be the best I've come across, better than the Larson which is a great antenna. It has a lot of gain and is very wide banded, so if you want to use it with a GMRS radio, there is no SWR problem. It's made for EMCOMM work and also folds over. I have had no problem hitting trees with it even though it is a taller antenna. I bought a 1/4 wave antenna to put on when off roading where trees are low.
Your best bet is to get a radio that you can mount in the vehicle that will stay there. If you use mostly VHF, a pull out radio that will not narrow band is a cheap way to go such as a Kenwood or Motorola, but you will have to find someone to program it, otherwise the Yaesu FT-7900 duel band is one of the better deals.
Doing the HT thing is a real pain and you are likely to damage the radio at some point. Stay away from the new China duel band radios, they have problems.
73's John