The system I'm scanning is Denver and I'm sure you have heard that Denver is now ESK enabled and that leaves my 250 useless. Also I have win500 connected to the scanner 24/7 to be able to stop the scanner from scanning remotely and therefore I can't use it and another application that accesses the scanner's data port.
If the ARC500 software does it, that doesn't work for me either - the software appears to require more memory than my machine has to offer as it hangs up and stops working. Of the list of software links provided on the wiki page, only one of them records both audio and screen capture but the screen capture quality isn't very good. Of course the better the quality, the more memory intensive it becomes.
Guess I'll just stick with recording audio unless someone knows of an application that will record audio and screen capture but isn't a resource hog and has good quality captures.