My scanning "modus operandi" is this: I create Favorites Lists for my home area as well as for travel destinations. Each Favorites List has its own Quick Key.
When I am at home or at my destination, I was turn on/off the Quick Keys for the appropriate Favorites Lists. I also have the full database off.
When I'm traveling between home and my destination, my Favorites Lists are off and the full database is on.
The scanner is connected to a GPS unit, so the appropriate "stuff" is turned on/off.
If you are not using a GPS device and use the zipcode setting to fix your scanner's location, you could reduce the range value to cut down on the number of systems being scanned. (The greater the range, the wider "scanning net" you are casting).