You will get interference on them since they are splinter channels, and narrowband, so neighboring signals will interfere.
There are such a limited number of them as referenced in the above post, and aircraft signals travel so far due to the nature of aircraft (high above the ground) that almost any air tactical frequency will get used in any area at one time or another.
Each area has their own pre-assigned air tac, however these areas are large and all it takes is two fires and they need to order a new one.
As far as I know right now there are no units pre-assigned number 21 or 22, they just use the original ones and those are used as overflow basically.
Birken