Might be some terminology/system things I am reading into, but I'll try to work though it.
The WyoLink system (like DTRS or any other APCO25/SmartZone/WAC systems) do have tower handoff's. If the subscriber radio is programmed correctly to the approved system template, it will switch to a better tower depending on RSSI just as a cellphone does. Is it possible that the radio could think that the tower its on is better than another falsely? Sure, but its not the norm. Worse case is that you can add a softkey or button to have the radio perform a site search and it will affliate to another site.
True, some people will travel statewide and keep one channel only on the radio, but thats how these systems are setup (and its a benefit factor on why they are bought). However, when you have areas of limited capacity or it becomes abused there are parameters that can be setup to restrict talkgroups or radios to certain geographical areas. This is called tresspassing and is setup in the zone controller(s).
For instance, a Green River PD car travels to Cheyenne. No one wants to hear or really have a need to have GPD in Cheyenne. The talkgroup could be set to no longer affiate to towers say..past Rawlins (depending on how the zones are setup). Now obviously we don't want to have the officer out of communications, so he can switch to a statewide or regional channel that everyone has access too for "calling" purposes. Since typically these channels are setup (not always) to be live 24/7, your not taxing resources. Again, it will only be active on towers that a radio is actually affiliated to.This was a widely used feature even back when SmartZone was developed. With the advent of everyone having a cellphone these days, not as much.
Warren operates an APCO25 system on base, and there is also a remote site out there, but not sure where. With the latest upgrades, there is a wireless system in the missle fields for data/video and other stuff that was installed by Boeing. My guess is that it operates in the 220-400 specturm and not the LMR federal specturm just due to the bandwidth requirements alone (Colorado and even Wyoming uses quite a bit of the VHF FedLMR so it would be counter productive). Just the fact being on a military base itself has all sorts of cool RF goodies from HF to Satcom. Although NITA tries to keep a good handle on some aspects of MilLMR stateside, doesn't always work
You don't want to see what a good friend of mine in the DC area goes thru with all the coordnation that happens down there.
As far as the RFI comment, thats purley from an engineering standpoint of the site. I could show you towers of death with all sorts of comms on it and never presented a problem in system design for users to get in/out of. If your nor properly filtering or using properly matched combiners, then the site can desense itself to the outside world - more so inband than multiband.
I had the same problem when our contract company decided to put all the TX antennas on the same level at a site. When one repeater was operating, and other was keyed up you could hear the desense (no crosstalk, just a low level buzz/hum). Getting them back out and properly placing the antennas and find tuning the cominbers solved that. These were with 100 watt repeaters that were also properly turned down to a resonable level.