If you're referring to Win500, yes, it will program the PSR-600. The 500 and 600 are basically the same radio, just in handheld and base versions, respectively. There are a couple of radio-specific features, but Win500 addresses these. Feel free to post any questions you have about the program in the software forum, someone will give you an answer, including Don (the author) himself.
You Should be able to. Did you download and unzip Win 500 into a single file? Check to make sure that you have downloaded the most recent version of Win 500. Unless you want to hand program the freq.s into win 500 it would be advisable to become a premium subscriber to RR so you can download directly into Win500 and to your scanner. Once you checked that all that is in order, check to make sure that you are using the right com port for your Usb cable and the scanner. That is enuff for now lets see where ya get and go from there. Hoser