If you're running Windows 10 you probably won't need any drivers. Mine just worked. Be warned, that when you run the software and try to read the radio you may be a pop up saying it can't find the comm port. Don't worry, this is normal. Just go to settings and you'll see the comm ports listed. Make sure it's highlighted and then try and read again and it should work fine. For some unknown reason you have to do this every time you open the software as it doesn't retain the setting.
Make sure you read the radio and save the code plug before you do any editing. This way, if you screw something up, you always have a code plug to go back to. I same all my code plugs going back six months in case I need to roll it back for some reason.
I love the FT-65R as a daily radio. It's got great sensitivity and the transmit audio is nice and clean. I like that the radio also only shows one band at a time. I know many people want two bands at a time (dual-watch) but I actually don't like that. I have a hard enough time listening to one frequency and paying attention, I don't need two! The radio also has the ability to create multiple zones (Yaesu calls them bands). Very convenient if you want to create frequency lists for different areas. I have one for Los Angeles, Ventura, Las Vegas and Colorado since I travel a lot.
Make sure you download the "Advanced" manual from Yaesu so you can learn all the cool settings and features.