It would help us help you if you could provide some more information...
-Tell us more about the repeater. Is it amateur radio, commercial/business users, transportation, public safety?
-Are you licensed to transmit on those frequencies?
-Specific details about the transmit and receive frequencies, emission type (analog, DMR, PMR, dPMR, TETRA, P25, NXDN, dStar), squelch type, etc. would be extremely helpful in helping us understand what you are attempting.
There are a number of different things that can be causing the issues you are experiencing. The more information you can provide, the better.