Can you unsquelch the radio so you hear just noise? One of the buttons on the side or front if
pressed and held for a few seconds should do that, if it has been programmed, or you can program
one button to do so if you have the program software, With radio unsquelched see if you can
hear transmissions that a second radio on same frequency can hear. If you hear the transmissions
then could be an issue with your tone setting or receive circuit. If you can't hear any transmissions
with radio unsquelched, then probably you have issues with receive circuits. I've seen that happen
with the Vertex VX417/420 series when one of the Ceramic Filters leads comes off its solder pad.
Assuming your radio is not under warranty and you feel comfortable disassembling it, you should
check both sides of the circuit board for any evidence of a part that has come loose off its solder
pad. Particularly check the ceramic filters (large white square components in the 417/420 series).
If this is a VHF band radio, try to program in your local NWS station (make sure it is on by
verifying with another radio) and see if you hear it.
My guess is you have receiver circuit issues.