FWIW, I just made a trip from Columbus, GA to Wichita, KS and back. Using RepeaterBook (Sorry, that's about the only thing available), I programmed 2m and .70m repeaters that were within about 20 miles of my route. I used a Yaesu FT-8900 set at 50W. I "checked in" on approximately 100 repeaters. Unscientifically, about half of the attempts opened the repeaters. I did not get a single response, however. In the bigger cities (B'ham, Little Rock, Tulsa & Wichita) I set the radio to scan with negative results for traffic.
I've done the same thing on a trip to Bay City, MI and back with similar results.
I refuse to say that amateur radio is doomed but it certainly doesn't sound promising.