I am confused... What you initially posted:
"My question is, is it really necessary to have repeater outputs programmed into a radio?
I was going to reprogram the radio with channels 1-22 & leave out the repeater outputs, unless there is a need for them to be programmed in."
Doesn't make sense with what you later posted:
"I already have the TX/RX frequencies and PL/DPL codes for some repeaters I'd like to program in."
When you are referring to "repeater outputs", do you mean the frequency that can be an output to a repeater or a simplex frequency? For example, on the 462.650/467.650 repeater pair you could be listening to a repeater on 462.650 or you could be having a simplex conversation on 462.650. So, in such a situation, you would want a memory location for simplex communication on 462.650 and you might want another memory location for repeater communications with the 462.650/467.650 pair.
In your initial post, you asked if you should leave out the "repeater outputs" but your later post stated that you already had some repeater pairs to program in. AFAIK, that radio has a thousand memory locations. Why would you delete 8 simplex channels that someone might be calling simplex on and add repeater pairs when you have enough memory locations to have the 22 simplex frequencies AND a ton of repeater pairs and tone combinations? To do otherwise makes absolutely no sense to me.
ETA: Perhaps the OP doesn't realize that the frequencies which are repeater outputs are also frequencies for simplex communications? To delete them would be to remove 8 potential communication channels from the radio. OP, in case you do not realize, when used for repeaters, the user radio transmits on 467.xxx and receives on 462.xxx of the repeater pair and for simplex (no repeater) operation, both user radios use 462.xxx for both transmit and receive without any external equipment. If you are planning on talking to a simplex user by transmitting on the repeater, that will appear as a one-sided conversation for some other repeater users and would get old for them and the owner(s) rather quickly.