Most likely the M-PA's memory battery has failed. Replace battery, reprogram, maybe put in new firmware if needed, on the ground it's an hour's job start to finish costing 50 bucks.
For the ISS...the next radio to be selected for replacement of it will be obsolete before it leaves the launchpad.
I understand the need to make sure the radio is compatible with the ISS environment but really their qualification process is something beyond being merely a little bit silly.
Ship them an XTS5000 with FPP and a battery power adaptor plus an antenna connector adapter and call it a day. Better yet, a dual band APX7000, VHF and UHF R1, and then they can work 2m and 70cm with a single modern and reliable radio.