Looks like you are trying to flash the radio, and Programmer can't find the correct file.
In the install directory, the folder 'radbin' is where programmer looks for the files.
'Track' has the base tracking files to recover a radio, but you need to know the specific file for your radio.
By default, 'Pers' hold any save personalities, unless you specify a different path.
Do you have anything in the radio now ? be sure to save everything before writing a new codeplug or flashing.