Mine seems to work acceptably with all sites programmed. A problem could theoretically arise when the radio is locked onto an adjacent site that does not carry the traffic you want to hear. The Unications are not like scanners that will rotate through sites looking for the target tg activity. It remains on a single site until its control channel is lost, then looks for the next receivable control channel. In practice, I'm usually able to hear geographically appropriate state agencies.
When I first programmed the G5, I had the system split into Zones: Z1, Z3 and Z5. But since Z3 is ridiculously large in terms of geography and number of sites, I decided that I would program all Zones and sites as one system. If I lived in a county that used FIRST for its PS comms, I would probably only program sites that normally carry my jurisdiction's traffic. You can have multiple versions of a single system on the G5, organized by Unication zones and knob positions. There are 8 knob position per Unication zone. I'm not sure of the number of Unication zones you can have per radio, but I have about 30 so far.