The Uniden PL/DPL decoder is quite slow, meaning that it sometimes take a quarter of a second for squelch to open up after a tone is detected. This is especially noticeable if you scan conventional channels, all with PL/DPL enabled, with priority enabled. When the scanner samples the priority channel, then reverts back to an active channel, there is a noticeable delay in squelch opening back up, resulting in someone clipped transmissions. As soon as you clear all of the PL/DPL tones from the channels, audio improves greatly.
So the bottom line is that if you have PL/DPL enabled on the channels you're listening to, especially if you're scanning them with priority enabled, you're going to experience this issue. Nothing you can do about it except to remove all of the PL/DPL tones from those channels, which may not be ideal if you have a lot of users sharing frequencies with different PL/DPL tones in the area.