Motorola ships their software these days with dire warnings about not even thinking of installing the programs under Vista or trying to use them if you somehow figure out how to install it that way. However, having said that, some people have reported success with using the "Run as..." feature of Vista for both installation of the software and operation of it, to run Vista in XP compatibility mode. I myself am not daring enough to try that on my department's radios, so I'm donig all my programming on a real XP machine, and that's what I'd recommend for now.