Well for starters, Phase I is FDMA and so slots do not apply. An FDMA (Phase I) talkgroup uses the entire bandwidth of the frequency, and thus no TDMA (Phase II) activity is possible on that frequency for the duration of the FDMA transmission.
Generally speaking, FDMA and TDMA are per-talkgroup, not per-system. If there are enough traffic channels at the site, there can be a mix of FDMA and TDMA talkgroup activity, with the caveat explained above that FDMA takes up the whole frequency with a single transmission (less efficient), while TDMA alternates the transmissions in time slots, thus allowing two transmissions per frequency (more efficient).
Oh and encryption really has no bearing on anything. Either the talkgroup is clear or encrypted, FDMA or TDMA...still has to follow the above rules.