Try to find one with an RS232 (DB9) serial port if you can. I was able to load frequencies though a USB-to-Serial Port adapter on a PRO-96, and PRO-2096 with no problem. However, when it came to the Uniden BC780-XLT, using ARC780, it wasn't supported, and I was unable to get it to work. It did work with the BC796D, and ARC250PRO, for loading frequencies, and control. However it did not work for flashing the radio's firmware, or the digital cards firmware. That operation still requires a true serial port.
So you'll probably save yourself some frustration down the road if you stick with a serial port.