The PRO-96 can hold up to 5500 channels, but only 500 of these are accessible at any one time. Then any one of the V-Folders (there are 10) may be swapped out as the active folder.
The V-Folders do come preloaded with a group of common high population areas. These may be changed to support your individual tastes. I'd make sure you save these in case you ever visit LA, NYC, Fort Worth, Dayton or Tucson (among those in the preloads).
I'd make one bank of the V-Folders a save location for your primary most used local settings and the other nine V-folders for what ever you want. Then when you want to swap out, you have your primary bank set in memory.