I run my PSR-500 on a Onmi-Link, Multiple Site, Simo system without issue.
I am able to move around in a given site with no problems, and can roam to other sites and quickly acquire the new CC. The site I listen to most (Site 3) has 5 transmitters with overlapping coverage. In my same footprint, I can also receive at least 3 other sites which are also simo.
I do have a few areas that I get some odd interference in some areas, but I get that with other scanners in those areas as well.