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I designed this circuit to utilize Teamspeak's 'push to talk' feature rather than the VOX feature that can be unreliable and difficult to dial in.
I did not use any isolation in my setup as I don't care if the old equipment fails, but good engineering practice will employ a 1:1 audio transformer in the audio line and an optocoupler between the serial port and the voltage comparator, and the common ground tie will be eliminated.