I have also used OP25 and it really cooks with just one RTL-SDR or NESDR. I have a RPi 3B+ using an old Nooelec TV tuner stick configured to handle the system I monitor in my office at work, running 24x7 even though I'm rarely there now.
Unitrunker 2.0 also works well but needs 2 SDRs.
For my use case SDRTrunk has been the easiest to get running - especially if you have access to the RR database and at least 2 SDRs or one SDR with enough bandwidth.
My experience is that UniTrunker does not require two dongles, and I've run multiple VCO's for each system I monitor. It does however take two VCO's; one for signal and one for voice channels in an EDACS system, fortunately we have BART on EDACS to experiment with. So a mix of different EDACS and P25 systems is no problem. I have about five control channels plugged in or added in SDRTrunk for Travis AFB and Beale as 380-400 Mhz as well as a few Federal systems in the 400-420 Mhz spectrum, though almost completely encrypted some voice slips through, and I have them assigned or preferred to one dongle. I used the Eprom editor to change the serial numbers of my dongles to make it easier to identify which is which, the utility can do more but the software may need the other info to identify the SDR model, so putting a 2, 3, 4, 5, 6, 7, on the serial number is all need be done. I also use two V4's, have two V3's, and had two Nano2+, one burned out as those run hot, in addition to a standard NooElec that came with the Upconverter to explore HF stuff, but I also got the other LNA's and other Ham it upconverters. It would be nice if SDRTrunk did not rely on the bandwidth model it's using as there should be a workaround just as with any regular scanner that is not limited by bandwidth as a result of not being able to display a segment used for trunking. If one wanted to see the extra bandwidth a second line display, whether SDRTrunk can make use of such a second display for extra bandwidth a different display and bandwidth model could be developed that mimics or virtualizes the 6Mhz of other SDR tuners.