Not really. Basically squelch on a digital channel follows an AND rule. Signal must be present AND it must match all required data constraints (system, group, and unit ID) before the radio must unmute, so I don't think that it makes much difference except that if squelch is set too tight, it can reduce effective sensitivity and receiver range.
Adjust squelch for proper operation on that frequency in analog, and when you switch to digital it'll be fine.