In California there are two wide area linked repeater systems on 220. One is a closed system and is called EARN, or Edison Amateur Radio Network. The audio linking is done on the Southern California Edison Motorola SmartZone Trunking System microwave to the peaks that have a trunked commercial site in addition to a ham repeater. The audio quality all over the system is outstanding.
The second system is called "CONDOR" and covers California from Sacramento south and parts of Arizona. I've never used it as I don't have a 220 mobile yet. I have the Kenwood TH-F6A with 220 but don't use it mobile as I don't use handhelds in the car due to distraction.
There are numerous 220 repeaters in California, especially southern California, where the 2m and 70cm bands are crowded.
The only currently available 220 mobile I"m aware of is an Alinco and it doesn't have many of the features that radios on other bands have such as alphanumeric channel display. In spite of that I plan to pick one up. My current plan, delayed because of funding problems, is to drill three holes in my car's rooftop, one for the scanner, one for the 2m/70cm rig, and one for the future installation of the 220 rig.
220 has interesting propagation qualities. It has some of the reflective characteristics of the 70cm band and some of the "terrain bending" characteristics of the 2m band. By getting each of these in the same signal you often can work repeaters from locations where a 2m and a 70cm repeater cannot be keyed up. This is the most interesting part of using this band and quite useful in many locations, especially in rural areas with mountainous terrain.