Here in the Northeast, CSX is notorious for using repeaters in the yard to prevent any issues of the headend receiving the conductor/brake/utility's portables. Generally, they work it where the ground-man is transmitting into the repeater, and listening on the output...and the head-end just transmits simplex on the output. This is the case in places like Selkirk, North Croton, Baltimore (maybe not any more), and Cumberland.
You also have railroads with very challenging terrain that can inhibit efficient communications via simplex/remote base operation as is standard, and aren't equipped with microwave or fiberoptic links to tie bases together. Ones that come to mind using repeaters at the moment are the NYS&W Northern Division, New England Central, and Vermont Railway System.
In a duplex system it generally works like this. You have your transmit channel, and your receive channel. *Generally* your transmit channel would be the road channel, and your receive channel would be the dispatcher's line to you. This allows the dispatcher to hear everything, but the dispatcher to speak to you interrupted or at a higher power that would completely step on other operations. When you're not speaking to the dispatcher, you would have the road channel as your TX & RX and operate normally, until the dispatcher requested you to call or you called him.