The following link goes to a chart which shows the current carrying capacity of automotive wires:
Wire Gauge Amps Ratings for 12 volt Automotive Systems
The size of the wire from the battery to the fuse block should coincide with
the lesser of these two things: The total amp rating of the fuse block or the sum of the draw of all devices that are fed by the fuse block. As a reminder there should be overcurrent protection for the wire(s) going from the battery to the fuse block, even if the wire run is short.
It appears your set-up is quite similar to what I've seen installed on firefighter personal vehicles (we can run emergency equipment in Kentucky) and a number of fire department service vehicles.
Something to toss out for consideration: You might want somethings being constant hot, other keys hot only when the ignition is on. In that case, two fuse blocks would do the trick, one hot and one ignition.