Some radios are MUCH easier than others to use. In my case, I used some Alinco single-band mobile rigs as they have every signal required to do a full repeater on the back of the radio on a DB9 connector. You can literally hardwire the DB9s together (in the right wiring pattern, of course) and have a minimally-functional repeater!
Some other rigs do too, the Yaesu FT-8800 and 8900 I know (I have them as well) although in some cases you have to reverse polarity of the COR (gives an "active high" but needs "active low" to TX or vice versa). The audio even matches, they have "9600 baud data" pins that have matched in/out levels.
I have a 220MHz repeater that used (and may well go back to) two Alinco rigs for the TX/RX. Audio was excellent - not so happy with the audio of the real repeater I recently got, thus may go back!
As for the two radios you mention, the hardest part as already mentioned is getting a proper COR (carrier operated relay) signal to key the transmitter when a received signal is heard. One option that springs to mind is to buy a (CTCSS) tone decoder board, connect it to the audio output of the scanner, and use a tone to control the repeater. If the scanner filters the low frequencies too much, you may have to connect the tone board to the discriminator audio of the scanner (be the same as connecting a "discriminator tap" for software such as UniTrunker used by many here).
Power level is an issue, I ran my Alinco 220 xmtr at 5W, it was only warm as long as I kept a fan going on it. Otherwise even at that level it got VERY hot. The 2M remote base xmtr I could run at higher power, since it only transmitted when I did - basically like I was using it directly.
Realize that duplexers can be the single most expensive part of a repeater system unless you find a good deal on used ones somewhere. If I were going to buy duplexers at anywhere near new prices, I'd go ahead and get some radio gear that would be easier to use than what you have first. Especially for the receiver, a scanner's front end is typically nowhere near as good as a real radio. (Although some ham rigs have such a "wide open" receiver range they aren't much better!)
It is also helpful to have a proper repeater controller in the system as well. The wiring I mentioned above simply allows automatic retransmission of audio. No control of the system is possible, though. Unless you are present with the repeater you would have no way to shut it down if something started going wrong. There are various repeater controllers available in the ham world, some very basic others quite fancy. Mine is an Arcom RC-210, it has a few extra features - thus a higher price tag.
One option for a tone decoder:
TD-5 Subaudible Tone Module
They also have a basic controller too:
COR-4 Module