Can be one of two possible things, assuming you actually have the proper frequencies programmed:
1 - The PL tone is incorrect
2 - You are out of range of the repeater
It would be helpful to to know what repeater you're talking about. FCC callsign, state, county, city, anything at all. You're posting in a nationwide GMRS forum.
Also, if finding an open repeater on that frequency is what you're alluding to (aka the Travel Channel), the PL tone used is 141.3 Hz. I would set the TX PL as 141.3 Hz, and leave the RX side CSQ.