Hi Runningman -
I live in Upstate SC as well.
If you have not updated the scanner in a year or more, then yes, you need to reprogram your scanner with updated information from the RadioReference database. There have been substantial changes to emergency services radio systems in Greenville County in the last 2 years. Almost all public safety agencies have moved to the Palmetto 800 system in the last 2 years. The Palmetto 800 system itself migrated to a full P25 system in the about 2 1/2 years ago.
While your scanner should be capable of receiving these communications, as others noted, your scanner does not support reception of simulcast systems well, and Greenville County runs on a 3-site simulcast site. That means that you may hear incomplete or garbled transmission once you update the programming in your scanner.
I would recommend you update the programming first, and see how it works. There are some tricks you can try to minimize the simulcast reception problem that might help you. I'd do that before you purchase a new radio.
Good luck.