I have a 2021 F150 and put radios in it a few years ago. I went out and snapped a few pics this morning that may help you.
I ran an 8 gauge wire and fuse that I got in a kit a Pep Boys, directly off the battery.
...through this grommet. I used an awl to poke a hole in the grommet and then a ballchain/magnet to retrieve the wire behind the glove compartment. I don't recall needing to do much removal of panels/pieces to get to the wire in the cab.

.
Then I ran the 8 gauge to under the rear seat where it is interrupted by a relay. Running wires in these trucks is a breeze. Panels pop off like legos.
I used the fuse panel by the front passenger area to handle the relay switching. I added an "add-a-fuse" that I got at Auto Zone. Circuit #2 is ignition switched with the exit delay where you need to open a door after turning the truck off to switch it off. The second, lower Add-a Fuse" in the photo is connected to a constant circuit, into a toggle switch, that closes a second relay. This lets me manually toggle a switch if I want to power the radio on while the truck is off.

.
I actually wanted an Anytone 578 but having a remote head was too high on my priority list so I went with two XPR4550 (V/U) instead. Not sure where you plan to put your 578...I know they have a bluetooth mic that doubles as a remote head now. That didn't exist when I did this install. The hardest part of the install, by far, was getting wires into the cubby for the head units, but that part probably doesn't apply to your install.

.
My radios draw a little bit of current even when "off" so I am glad I have the relay remove power completely. You should put a meter on the Anytone to see what it draws when "off". You may want to add a relay to save your battery. These trucks seem to have enough parasitic draw as it is with all the electronics. I'm about ready to stick a solar panel on mine to keep it topped off, but that's another project.
Hopefully some of this is applicable and helps you out. Feel free to ask me any questions.