1.Uninstall program software
2.In Device Manager, uninstall the hardware.
3. Reboot, cold boot.
4.Reinstall the program software and the device--in the exact sequence that the instructions call for.
Sometimes the USB device must be present before software is installed, sometimes it must NOT be present until after the software is installed.
5.After everything is reinstalled, reboot.
And don't expect it to work on more than one USB port. The way windows enumerates USB ports and devices, you need a separate installation for each one. Some software and hardware also can only be configured for COM1-COM4, or COM1-COM16, because it is old and poorly written. Windows assigns ports up to 255, so if the software documentation does say it supports that, you may also have to UNinstall other devices, so that this installation can take place on a lower number port. Windows will make installations on the lowest available port number first, regardless of how man are in use.
If it still doesn't work...possible hardware failure. But the configuration is both subtle and critical, and not widely explained.