I can't offer much...it installed on Windoze 10 for me without any problems. Dug out my activation key and I was in business. Maybe try booting into Safe Mode and see if it will load and install then?
I am running WIN500 on Windows 10, but had a lot of issues. I think my final issue has to do with the "Virus Protection" software I am using causing "delays' when doing certain things. But it is usable.
I run Win500 on Windows 7.... but a few years ago my computer automatically upgraded itself to Windows 10 (that's another thread by itself) and Win500 ran just fine. No problems here.....
(I eventually re-installed Windows 7 because I absolutely hated Windows 10 for other reasons.)