Amsat, not AmStat
It's Amsat, not Amstat.
www.amsat.org
The shuttle has a number of radios on a host of frequencies, most of which have to do with telemetry or comms back to mission control. They used to also have an amateur station that was used occasionally (rarely is more like it) but I have no idea if it is still there (remember, there are multiple shuttles, and they are not all identical).
The International Space Station has two Amateur Radio stations for earth contacts. I've heard the astronauts talking to people on the surface on several occasions. Their radio is currently in cross-band repeat mode, so instead of hearing them, they are auto-retransmitting earth station contacts - uplink is 437 something, and downlink is 145.800.
146.94 is an amateur radio 2 meter repeater frequency. Around here, a prominent one run by the TRO. Won't hear any astronauts there, but might hear guys talking about having talked to the astronauts.
144.34 is the APRS packet frequency. Down there, all you'll hear is digital noise, unless you feed it in to your sound card and get the computer program that translates it. Then what you'll see is where various amateurs cars are as they motor about the town.
421.25 is in the CW portion of the amateur 70cm band. While you might hear some weak signal work there, it won't be from space. The satellite downlink portion is in the 430.xxx range.
And the "operational" comms will not be in either of these ranges - 144 to 148 and 420-450 are reserved for amateur radio. NASA has their own blocks for the "real" mission stuff. I have no idea what they are.