Uniden doesn't support OS X.
But you can run windows in vmware or parallels on your mac, to run sentinel and program your radio. It works best with an sdcard reader and not hooking up your radio directly to the USB port.
I do it all the time and have had no issues.
There are several monitor programs on this site that will run on a mac but are not for programming your radio.
We need more mac users to pressure Uniden for mac support. It is surprising because most electronics do support both mac and windows now.