We've got a 2m repeater at an FM broadcast site, I think it's 20 or 25kW. Our repeater antennas (4 of them coupled with a phasing harness) are relatively close to the FM tx antenna up top.
Was previously an MSR2000, is now a Quantar. Phelps-Dodge duplexer. We do have measurable RF (up to 1W if I remember correctly) coming back down the feedline, so we had a stub filter tuned to the FM station frequency and we use a circulator with a dummy load just in case.
Not sure how necessary the stub filter was, but I removed it when we changed to the Quantar, it doesn't see a measurable noise floor difference or change in sensitivity with or without the filter.
Bottom line: Yes, if you have a good quality repeater, even if it's older, and at least a halfway-decent duplexer, you're probably fine.
The worst setup might be something like a Yaesu DR-2X repeater
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