Depending on the source of your information, the PL-259 connector has a bit of loss and impedance mis-match at higher frequencies. Some will say the PL-259 is a horrible connector and should not be allowed in any radio installation. Some say there's nothing wrong with the connector as long as you understand its limitations.
That said, for most applications, if the PL-259 is
properly installed, it usually isn't a problem on 144 and 440 MHz amateur radio installations. I emphasize "
properly installed". I hedged my comment yesterday by saying "possible source".
@prcguy got right to the point by saying "unless it’s put on wrong".
Installing a PL-259 on a piece of RG-8, or similar, coax is an amateur radio right of passage. Especially, if it's the solder type of connector. Getting solder to flow between the body of the connector and the shield of the coax without melting the dielectric is a challenge. It's my understanding that the the telecommunications industry has gone to the crimp type connectors. I ass-u-me they've done so because the crimp type is easier and faster to install in the field than solder type with less chance of making a poor connection.
If your coax has PL-259 connectors that were factory crimped or crimped by an experienced person in the field using the correct tools, then your PL-259s are probably OK for your application. If they were soldered in the field, then they might, emphasize "might", cause a problem.
Two interesting websites:
You often read or hear that every PL259 connector on your coax adds 0,5dB loss. This might be the truth on UHF and higher. But on HF/VHF tha...
pe4bas.blogspot.com